SimphoSOFT® application notes

The following collection of application notes contains case studies of analysis and optimization of particular non-linear materials with the help of our modeling software SimphoSOFT®. SimphoSOFT is an ideal tool, if not the only one for most of the described cases, to obtain the same level of insight on light interaction with photo-activated materials presented in these case studies.

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Material	SimphoSOFT® Benefits	SimphoSOFT® Transition Modules
mEGFP Alexa 488	two-photon scanning microscopy accurately calculate output signal from fluorescent dyes intelligently choose a multi-photon absorber and a laser to reach necessary resolution choose the best laser for the money (Ti:Sapphire vs. fiber lasers analysis)
STED microscopy	stimulated emission optimize the stimulated fluorescence signal help designing STED microscope
Alexa 488 Alexa 532 Alexa 647	fluorescent probes analysis (flow cytometry) accurately estimate fluorescent and phosphorescent signals to avoid using compensation methods develop new and optimize existing dye sets for multi-dyes and multi-laser configurations include multi-photon dyes into existing dye sets
Tm3+	amplification (pulsed seed) optimize rare-earth doped amplification material example of two variables: pump energy and the sample length sample properties are similar to single-mode fiber accurate modeling of multiple beam propagation
Tm3+	CW seed amplification optimize rare-earth doped amplification material example of two variables: pump energy and the sample length sample properties are similar to single-mode fiber accurate modeling of multiple beam propagation
dye G47	two-photon absorption, z-scan fitting predict a range of low laser beam energy values for accurate Z-scan measurements within a traditional two-level model accurate characterization of two-photon absorption cross-section for high laser beam energy values by using more accurate models of three or more energy levels
AF455	two-photon absorption allows setting up a complex energy level diagram, with singlet and triplet states no need to modify numerical algorithm
general absorber	diffraction accurate modeling beam divergence modeling optically thick samples save computational time when negligible diffraction term is switched off
material with large nonlinear index of refraction, n2	Kerr effect ideal for pre-screening materials to avoid dangerous intensity levels formation detailed analysis of strong self-focusing which leads to increased light intensity
semiconductor quantum dots CdS	two-photon absorption modeling of excitation and relaxation of QDs user can assess pulse distortion and intensity saturation
Yb3+ ⇒ Er3+	energy transfer, upconversion unlimited number of energy levels and ET transitions available allows improving accuracy of computations optimize hybrid material by changing types of ions optimize dopant concentrations to improve performance optimize quantum yield for light emission can simulate some types of lasers, amplifiers, PDT, photosynthesis, FRET
Tm3+	cross-relaxation (self-quenching) predict how valuable cross-relaxation and upconversion during energy transfer accurately recognize dominating processes to optimize energy transfer detect undesired photo-bleaching optimize dopant concentrations to improve performance optimize quantum yield for light emission
Ho3+	cross-relaxation (self-quenching) predict how valuable cross-relaxation and upconversion during energy transfer accurately recognize dominating processes to optimize energy transfer detect undesired photo-bleaching optimize dopant concentrations to improve performance optimize quantum yield for light emission
photosynthetic reaction center	electron transfer perfect research tool to gain more insight on processes of microscopic level electron transfer
Photofrin (photodynamic therapy)	energy transfer, with chemical reactions plan and guide PDT to avoid dangerous levels of irradiations while reaching maximum levels of treatment optimize parameters of PDT by predicting active oxygen reaction rate and unwanted photo-bleaching

	SimphoSOFT® can be purchased as a single program and can be also configured with Energy Transfer add-on , Multi-Beam add-on , Optimization add-on , Z-scan add-on , and MPA Info+ add-on for an additional charge. Please, contact our sales staff for more information e-mail phone: +1 (973) 621-2340
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